Orthologous gene-expression profiling in multi-species models: search for candidate genes

被引：92

作者：

Grigoryev, DN

Ma, SF

Irizarry, RA

Ye, SQ

Quackenbush, J

Garcia, JGN

机构：

[1] Johns Hopkins Univ, Div Pulm & Crit Care Med, Ctr Translat Resp Med, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Ctr Translat Resp Med, Baltimore, MD 21224 USA

[3] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA

[4] Inst Genom Res, Rockville, MD 20850 USA

来源：

GENOME BIOLOGY | 2004年 / 5卷 / 05期

关键词：

D O I：

10.1186/gb-2004-5-5-r34

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

引用

页数：13

共 51 条

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