Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans

被引：58

作者：

Mertz, H ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

来源：

GUT | 2002年 / 51卷

关键词：

D O I：

10.1136/gut.51.suppl_1.i29

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Several features of the irritable bowel syndrome (IBS) suggest involvement of the emotional limbic system in the brain. Abnormalities which upregulate afferent (sensory) signal intensity anywhere in this system, from the gastrointestinal tract to the brain, could induce hypersensitivity, leading to the pain and discomfort that characterise IBS and other functional disorders. Functional gastrointestinal disorders are likely to be heterogeneous given the complexity of the afferent system, and a number of different perturbations are possible. Intestinal hypersensitivity to pain and discomfort and associated reflex alterations in motility might explain the symptoms of functional bowel diseases.

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页码：I29 / I33

页数：5

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