Three-dimensional structures of the TAFII-containing complexes TFIID and TFTC

被引：103

作者：

Brand, M ^{[1
]}

Leurent, C ^{[1
]}

Mallouh, V ^{[1
]}

Tora, L ^{[1
]}

Schultz, P ^{[1
]}

机构：

[1] Univ Strasbourg 1, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch, France

来源：

SCIENCE | 1999年 / 286卷 / 5447期

关键词：

D O I：

10.1126/science.286.5447.2151

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

TBP (TATA-binding protein)-associated factors (TAF(II)s) are components of Large multiprotein complexes such as TFIID, TFTC, STAGA, PCAF/GCN5, and SAGA, which play a key role in the regulation of gene expression by RNA polymerase II. The structures of TFIID and TFTC have been determined at 3.5-nanometer resolution by electron microscopy and digital image analysis of single particles. Human TFIID resembles a macromolecular clamp that contains four globular domains organized around a solvent-accessible groove of a size suitable to bind DNA. TFTC is Larger and contains five domains, four of which are similar to TFIID.

引用

页码：2151 / 2153

页数：3

共 31 条

[1] Regulation of gene expression by multiple forms of TFIID and other novel TAFII-containing complexes [J].

Bell, B ;

Tora, L .

EXPERIMENTAL CELL RESEARCH, 1999, 246 (01) :11-19

[2] hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II [J].

Bertolotti, A ;

Lutz, Y ;

Heard, DJ ;

Chambon, P ;

Tora, L .

EMBO JOURNAL, 1996, 15 (18) :5022-5031

[3] Human TAFII28 and TAFII18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family [J].

Birck, C ;

Poch, O ;

Romier, C ;

Ruff, M ;

Mengus, G ;

Lavigne, AC ;

Davidson, I ;

Moras, D .

CELL, 1998, 94 (02) :239-249

[4] Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction [J].

Brand, M ;

Yamamoto, K ;

Staub, A ;

Tora, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18285-18289

[5] DISTINCT TFIID COMPLEXES MEDIATE THE EFFECT OF DIFFERENT TRANSCRIPTIONAL ACTIVATORS [J].

BROU, C ;

CHAUDHARY, S ;

DAVIDSON, I ;

LUTZ, Y ;

WU, J ;

EGLY, JM ;

TORA, L ;

CHAMBON, P .

EMBO JOURNAL, 1993, 12 (02) :489-499

[6] 3-DIMENSIONAL STRUCTURE OF YEAST RNA POLYMERASE-II AT 16-A RESOLUTION [J].

DARST, SA ;

EDWARDS, AM ;

KUBALEK, EW ;

KORNBERG, RD .

CELL, 1991, 66 (01) :121-128

[7]

GANGLOFF YG, IN PRESS MOL CELL BI

[8] A subset of TAFIIs are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation [J].

Grant, PA ;

Schieltz, D ;

Pray-Grant, MG ;

Steger, DJ ;

Reese, JC ;

Yates, JR ;

Workman, JL .

CELL, 1998, 94 (01) :45-53

[9] RNA polymerase II as a control panel for multiple coactivator complexes [J].

Hampsey, M ;

Reinberg, D .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (02) :132-139

[10] Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions? [J].

Hoffmann, A ;

Oelgeschlager, T ;

Roeder, RG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :8928-8935

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