Predominance of CRF02-AG and CRF06-cpx in Niger, west Africa

被引：29

作者：

Mamadou, S

Montavon, C

Ben, A

Djibo, A

Rabiou, S

Mboup, S

Delaporte, E

Peeters, M

机构：

[1] IRD, Retrovirus Lab, UR36, F-34032 Montpellier 1, France

[2] Univ Montpellier 1, Montpellier, France

[3] Natl Hosp Niamey, Niamey, Niger

[4] CHU Le Dantec, Lab Bacteriol Virol, Dakar, Senegal

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2002年 / 18卷 / 10期

关键词：

D O I：

10.1089/088922202760072357

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A total of 110 HIV-1-positive samples obtained in 1997 (n = 44) and 2000 (n = 66) were genetically characterized in the V3-V5 envelope region and the p24 gag region. The majority of the strains were CRF02-AG (54.3%) or CRF06-cpx (18.1%) in env and gag. More than 9% of the samples were recombinants between CRF02 and CRF06; 9 were CRF06 in env but CRF02 in gag, and for one sample the opposite was seen. Overall for 23 (20.9%) samples, the subtype designation was different between env and gag, and in 20 of these 23 samples a CRF was involved in the recombination event. No significant differences were seen between subtype distributions in 1997 and 2000, except that the proportion of recombinants increased from 13.6% in 1997 to 27.2% in 2000.

引用

页码：723 / 726

页数：4

共 15 条

[1] Short communication - Molecular characterization of the envelope transmembrane glycoprotein of 13 new human immunodeficiency virus type 1 group O strains from six different African countries [J].

Bibollet-Ruche, F ;

Peeters, M ;

Mboup, S ;

Ekaza, E ;

Gandji, R ;

Torimiro, J ;

Mpoudi, EN ;

Amblard, J ;

Dibanga, G ;

Saidou, M ;

Esu-Williams, E ;

Haesevelde, MV ;

Saman, E ;

Delaporte, E .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (14) :1281-1285

[2] GENETIC-RELATIONSHIPS DETERMINED BY A DNA HETERODUPLEX MOBILITY ASSAY - ANALYSIS OF HIV-1 ENV GENES [J].

DELWART, EL ;

SHPAER, EG ;

LOUWAGIE, J ;

MCCUTCHAN, FE ;

GREZ, M ;

RUBSAMENWAIGMANN, H ;

MULLINS, JI .

SCIENCE, 1993, 262 (5137) :1257-1261

[3] Simplified strategy for detection of recombinant human immunodeficiency virus type 1 group M isolates by gag/env heteroduplex mobility assay [J].

Heyndrickx, L ;

Janssens, W ;

Zekeng, L ;

Musonda, R ;

Anagonou, S ;

Van der Auwera, G ;

Coppens, S ;

Vereecken, K ;

De Witte, K ;

Van Rampelbergh, R ;

Kahindo, M ;

Morison, L ;

McCutchan, FE ;

Carr, JK ;

Albert, J ;

Essex, M ;

Goudsmit, J ;

Asjö, B ;

Salminen, M ;

Buvé, A ;

van der Groen, G .

JOURNAL OF VIROLOGY, 2000, 74 (01) :363-370

[4]

*JOINT UN PROGR HI, 2000, GLOB HIV AIDS STD SU

[5] A SIMPLE METHOD FOR ESTIMATING EVOLUTIONARY RATES OF BASE SUBSTITUTIONS THROUGH COMPARATIVE STUDIES OF NUCLEOTIDE-SEQUENCES [J].

KIMURA, M .

JOURNAL OF MOLECULAR EVOLUTION, 1980, 16 (02) :111-120

[6] Lessons from the second AIDS virus, HIV-2 [J].

Marlink, R .

AIDS, 1996, 10 (07) :689-699

[7]

Montavon C, 2000, J ACQ IMMUN DEF SYND, V23, P363

[8]

Montavon C, 2002, J ACQ IMMUN DEF SYND, V29, P522, DOI 10.1097/00126334-200204150-00014

[9]

OUSSEINI H, 1991, B SOC PATHOL EXOT, V84, P235

[10] Predominance of subtype A and G HIV type 1 in Nigeria, with geographical differences in their distribution [J].

Peeters, M ;

Esu-Williams, E ;

Vergne, L ;

Montavon, C ;

Mulanga-Kabeya, C ;

Harry, T ;

Ibironke, A ;

Lesage, D ;

Patrel, D ;

Delaporte, E .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (04) :315-325

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