Is near-infrared spectroscopy living up to its promises?

The first clinical application of near-infrared spectroscopy (NIRS) was made 20 years ago on the head of newborn infants under intensive care. Since then NIRS has yielded much credible and some important clinical research data. The most important results have been obtained using the cumbersome but quantitative techniques for measuring cerebral blood flow, cerebral blood volume, or venous oxygen saturation with manipulation of FiO(2) or impeding venous outflow from the brain. The continuous nature of NIRS has been combined with monitoring of arterial pressure to obtain measures of cerebrovascular regulation, but this method has not been applied on a larger scale. Second-generation instruments allow a running estimate of vascular haemoglobin oxygen saturation, named the tissue oxygenation index (TOI), in absolute terms. Applied to the head, this is a surrogate measure of cerebro-venous saturation, an important variable in neuro-intensive care. The precision, however, is insufficient to be useful. In conclusion: clinical application is not in sight. (c) 2006 Elsevier Ltd. All rights reserved.