Osteoblastic niche supports the growth of quiescent multiple myeloma cells

被引：66

作者：

Chen, Zheng ^{[1
]}

Orlowski, Robert Z. ^{[2
]}

Wang, Michael ^{[2
]}

Kwak, Larry ^{[2
]}

McCarty, Nami ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Ctr Stem Cell & Regenerat Dis, Brown Fdn Inst Mol Med Prevent Human Dis IMM, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA

来源：

BLOOD | 2014年 / 123卷 / 14期

关键词：

TRACKING; VIVO;

D O I：

10.1182/blood-2013-07-517136

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The heterogeneity of multiple myeloma (MM) contributes to variable responses to therapy. In this study, we aim to correlate the heterogeneity of MM to the presence of quiescent cells using the PKH26 dye. We tracked the rare quiescent cells in different niches of the bone marrow by allowing the cells to cycle in vivo. Surprisingly, quiescent PKH+ MM cells prefer to reside within the osteoblastic niches of the bone marrow (PKH+/OS) rather than the vascular (VS) niches or the spleen. These cells (PKH+/OS) displayed enhanced stemlike properties by forming colonies in semisolid medium. PKH+ cells were highly tumorigenic compared with PKH- cells and were resistant to a variety of drugs. However, the levels of drug resistance were somewhat similar regardless of where the PKH+ cells were isolated. Our data indicate that osteoblastic niches support the growth of quiescent PKH+ cells and allow them to have stemlike functions.

引用

页码：2204 / 2208

页数：5

共 8 条

[1]

Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules [J].