Sceptrin as a potential biosynthetic precursor to complex pyrrole - Pyrrole-imidazole alkaloids: The total synthesis of ageliferin

被引：101

作者：

Baran, PS ^{[1
]}

O'Malley, DP ^{[1
]}

Zografos, AL ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 20期

关键词：

D O I：

10.1002/anie.200453937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microwave-induced magic: There is a widely held conviction that the antiviral marine alkaloid ageliferin 1 arises biosynthetically from a Diels-Alder reaction which, although possible, has yet to materialize in the laboratory. A total synthesis of 1 from sceptrin is now reported that has led to a new hypothesis for how 1 and other dimeric pyrrole-imidazole alkaloids might be formed in nature.

引用

页码：2674 / 2677

页数：4

共 25 条

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