Synthesis of primary amines: First homogeneously catalyzed reductive amination with ammonia

被引：230

作者：

Gross, T ^{[1
]}

Seayad, AM ^{[1
]}

Ahmad, M ^{[1
]}

Beller, M ^{[1
]}

机构：

[1] Univ Rostock eV, IfOK, D-18055 Rostock, Germany

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1021/ol0200605

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] The synthesis of primary amines via reductive amination of the corresponding carbonyl compounds with aqueous ammonia is achieved for the first time with soluble transition metal complexes. Up to an 86% yield and a 97% selectivity for benzylamines were obtained in the case of various benzaldehydes by using a Rh-catalyst together with water-soluble phosphine and ammonium acetate. In the case of aliphatic aldehydes, a bimetallic catalyst based on Rh/Ir gave improved results.

引用

页码：2055 / 2058

页数：4

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