Can eccentric arterial plaques alone cause flow stagnation points and favour thrombus incorporation?

被引：1

作者：

Beneli, Cristina T. ^{[1
]}

Barbosa, Priscila F. ^{[1
]}

Floriano, Elaine M. ^{[1
]}

Abreu, Monica A. ^{[1
]}

Ramalho, Fernando S. ^{[2
]}

Elias Junior, Jorge ^{[3
]}

Rossi, Marcos A. ^{[1
]}

Ramos, Simone G. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Dept Surg & Anat, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Dept Radiol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY | 2009年 / 90卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

atherosclerosis; blood flow; neointima; stenosis; WALL SHEAR-STRESS; CORONARY ATHEROSCLEROSIS; COMPENSATORY ENLARGEMENT; LIPID DEPOSITION; HORSESHOE VORTEX; CELLS; BIFURCATION; STENOSIS; PATHOGENESIS; EXPRESSION;

D O I：

10.1111/j.1365-2613.2008.00630.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We have used an experimental model of aorta stenosis, with a Plexiglas plug, simulating a stable atheromatous plaque that promotes local turbulence and thrombosis. With animal survival of more than 24 h, we followed the partial fibrinolysis of the thrombus as well as its posterior organization and incorporation to the arterial wall as a neointima for up to 30 days. The mushroom plug form permitted the development of recirculation and stasis areas around it, favouring this evolution. Despite noted limitations, this study demonstrates that thrombus incorporation can contribute to plaque extension, as it can promote recirculation and stasis areas.

引用

页码：295 / 310

页数：16

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