Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation

被引：22

作者：

Green, E. K. ^{[1
]}

Norton, N. ^{[1
]}

Peirce, T. ^{[1
]}

Grozeva, D. ^{[1
]}

Kirov, G. ^{[1
]}

Owen, M. J. ^{[1
]}

O'Donovan, M. C. ^{[1
]}

Craddock, N. ^{[1
]}

机构：

[1] Univ Cardiff Wales, Dept Psychol Med, Cardiff CF14 4XN, Wales

来源：

MOLECULAR PSYCHIATRY | 2006年 / 11卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/sj.mp.4001853

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：798 / 799

页数：2

共 11 条

[1] Schizophrenia and affective disorders - Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family [J].

Blackwood, DHR ;

Fordyce, A ;

Walker, MT ;

St Clair, DM ;

Porteous, DJ ;

Muir, WJ .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (02) :428-433

[2] Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia [J].

Callicott, JH ;

Straub, RE ;

Pezawas, L ;

Egan, MF ;

Mattay, VS ;

Hariri, AR ;

Verchinski, BA ;

Meyer-Lindenberg, A ;

Balkissoon, R ;

Kolachana, B ;

Goldberg, TE ;

Weinberger, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (24) :8627-8632

[3] Chromosome 1 loci in Finnish schizophrenia families [J].

Ekelund, J ;

Hovatta, I ;

Parker, A ;

Paunio, T ;

Varilo, T ;

Martin, R ;

Suhonen, J ;

Ellonen, P ;

Chan, GY ;

Sinsheimer, JS ;

Sobel, E ;

Juvonen, H ;

Arajärvi, R ;

Partonen, T ;

Suvisaari, J ;

Lönnqvist, J ;

Meyer, J ;

Peltonen, L .

HUMAN MOLECULAR GENETICS, 2001, 10 (15) :1611-1617

[4] Replication of 1q42 linkage in Finnish schizophrenia pedigrees [J].

Ekelund, J ;

Hennah, W ;

Hiekkalinna, T ;

Parker, A ;

Meyer, J ;

Lönnqvist, J ;

Peltonen, L .

MOLECULAR PSYCHIATRY, 2004, 9 (11) :1037-1041

[5] Genomewide linkage scan in Schizoaffective disorder - Significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13 [J].

Hamshere, ML ;

Bennett, P ;

Williams, N ;

Segurado, R ;

Cardno, A ;

Norton, N ;

Lambert, D ;

Williams, H ;

Kirov, G ;

Corvin, A ;

Holmans, P ;

Jones, I ;

Gill, M ;

O'Donovan, MC ;

Owen, MJ ;

Craddock, N .

ARCHIVES OF GENERAL PSYCHIATRY, 2005, 62 (10) :1081-1088

[6] Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects [J].

Hennah, W ;

Varilo, T ;

Kestilä, M ;

Paunio, T ;

Arajärvi, R ;

Haukka, J ;

Parker, A ;

Martin, R ;

Levitzky, S ;

Partonen, T ;

Meyer, J ;

Lönnqvist, J ;

Peltonen, L ;

Ekelund, J .

HUMAN MOLECULAR GENETICS, 2003, 12 (23) :3151-3159

[7] Disrupted in Schizophrenia 1 (DISC1): Association with schizophrenia, schizoaffective disorder, and bipolar disorder [J].

Hodgkinson, CA ;

Goldman, D ;

Jaeger, J ;

Persaud, S ;

Kane, JM ;

Lipsky, RH ;

Malhotra, AK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (05) :862-872

[8] A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42 [J].

Macgregor, S ;

Visscher, PM ;

Knott, SA ;

Thomson, P ;

Porteous, DJ ;

Millar, JK ;

Devon, RS ;

Blackwood, D ;

Muir, WJ .

MOLECULAR PSYCHIATRY, 2004, 9 (12) :1083-1090

[9] Design of case-controls studies with unscreened controls [J].

Moskvina, V ;

Holmans, P ;

Schmidt, KM ;

Craddock, N .

ANNALS OF HUMAN GENETICS, 2005, 69 :566-576

[10] A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder [J].

Sachs, NA ;

Sawa, A ;

Holmes, SE ;

Ross, CA ;

DeLisi, LE ;

Margolis, RL .

MOLECULAR PSYCHIATRY, 2005, 10 (08) :758-764

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