On the complication risk of early amniocentesis versus standard amniocentesis

In the last 6 years early amniocentesis for the prenatal diagnosis of chromosome abet-rations has been established in many centers worldwide, but knowledge about the gynecological safety of the procedure is sparse, From 1990 to 1995 al the Evangelisches Krankenhaus Oberhausen (Germany) 3,277 early amniocenteses (between weeks 11 and 14) and 1,808 standard amniocenteses were performed in low-risk indication groups (advanced maternal age and anxiety), A complete follow-up including reports of fetal outcome was obtained in 4,444 cases (87.5%), A pregnancy age-related abortion rate was determined with a slightly higher rate of abortions up to week 28 of gestation in early amniocentesis, The total abortion rate up to week 28 after the procedure for cases with complete follow-up was 2% in early amniocentesis, Compared to standard amniocentesis performed under the same clinical conditions with an abortion rate of 1.3%, there is no statistical difference between early and standard amniocentesis (p = 0.0971), Hip and foot dislocations (22 cases) and pulmonary distress syndromes (8 newborns) showed no significant correlation with the gestational week, Given the high normal background rate of spontaneous abortions in the early period of pregnancy without an invasive procedure, early amniocentesis can be considered as a safe alternative to chorionic villus sampling and standard amniocentesis.