Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages

被引：81

作者：

Kim, JY ^{[1
]}

Jung, KS ^{[1
]}

Jeong, HG ^{[1
]}

机构：

[1] Chosun Univ, Dept Pharm, Coll Pharm, Res Ctr Prot Mat, Kwangju 501759, South Korea

来源：

FEBS LETTERS | 2004年 / 569卷 / 1-3期

关键词：

kahweol; cafestol; cyclooxygenase-2; NF-kappa B; macrophage;

D O I：

10.1016/j.febslet.2004.05.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inducible cyclooxygenase-2 (COX-2) has been suggested to play a role in the processes of inflammation and carcinogenesis. Recent studies have shown the chemoprotective effects of kahweol and cafestol, which are coffee-specific diterpenes. This study investigated the effects of kahweol and cafestol on the expression of COX-2 in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Kahweol and cafestol significantly suppressed the LPS-induced production of prostaglandin E-2, COX-2 protein and mRNA expression, and COX-2 promoter activity in a dose-dependent manner. Furthermore, kahweol blocked the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity. These results will provide new insights into the anti-inflammatory and anti-carcinogenic properties of kahweol and cafestol. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：321 / 326

页数：6

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