Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance

被引：35

作者：

Stokvis, E

Rosing, H

López-Lázaro, L

Schellens, JHM

Beijnen, JH

机构：

[1] Slotervaart Hosp, Dept Pharm & Pharmocol, Netherlands Canc Inst, NL-1066 EC Amsterdam, Netherlands

[2] Pharma Mar SA, Res & Dev, Madrid 28770, Spain

[3] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

[4] Univ Utrecht, Fac Pharmaceut Sci, Dept Biomed Anal, Div Drug Toxicol, NL-3508 TB Utrecht, Netherlands

来源：

BIOMEDICAL CHROMATOGRAPHY | 2004年 / 18卷 / 06期

关键词：

Kahalalide F; human plasma; solid phase extraction; multiple reaction monitoring LC-MS/MS;

D O I：

10.1002/bmc.392

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC-MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC-MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC-MS/MS assays of drugs in biological matrices. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：400 / 402

页数：3

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