New aziridine sulfide ligands for palladium-catalyzed asymmetric allylic alkylation

被引：25

作者：

Braga, AL ^{[1
]}

Paixao, MW ^{[1
]}

Milani, P ^{[1
]}

Silveira, CC ^{[1
]}

Rodrigues, OED ^{[1
]}

Alves, EF ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

SYNLETT | 2004年 / 07期

关键词：

asymmetric allylic alkylation; asymmetric catalyst; palladium; chiral pool; aziridine; S; N-ligands;

D O I：

10.1055/s-2004-825588

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aziridine sulfides, a new type of chiral S,N-ligand, have been easily synthesized in a straightforward synthetic route, from an inexpensive and easily available chiral pool. They were used in the Pd-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-properyl acetate with dimethymalonate anion, furnishing the alkylated product in excellent yields and stereoselectivity up to 99%.

引用

页码：1297 / 1299

页数：3

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