Silver has been used for centuries as an antimicrobial agent to reduce bioburden and prevent infection. Its usage diminished when antibiotics were introduced but remained one of the most popular agents for wound infections, especially in burned patients. Incorporation of silver into a range of hygiene and healthcare applications has increased, and this has raised concerns over the development of silver resistance, toxicity, methods of testing products and evidence of efficacy. The published evidence for resistance and toxicity is limited and associated with frequent and high levels of silver used. Increasing evidence of improved antimicrobial activity of nanoparticles of silver and possible dual immunomodulatory effects are exciting. This may lead to further product development as potential alternative preservatives as some currently available preservatives have an increasing incidence of allergic reactions. Acknowledging the role of the carrier is important, and as silver is active when in solution, opens a window of opportunity in personal hygiene area. This is important in an age when multiple antibiotic-resistant bacteria are becoming prevalent.
机构:
St Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Washington Univ, Sch Med, St Louis, MO USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Asz, Jose
;
Asz, Daniel
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机构:
Hosp Gen Dr Manuel Gea Gonzalez, Dept Dermatol, Mexico City, DF, MexicoSt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Asz, Daniel
;
Moushey, Robin
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机构:
St Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Washington Univ, Sch Med, St Louis, MO USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Moushey, Robin
;
Seigel, Jennifer
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机构:
St Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Washington Univ, Sch Med, St Louis, MO USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Seigel, Jennifer
;
Mallory, Susan B.
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机构:
Washington Univ, Sch Med, St Louis, MO USA
St Louis Childrens Hosp, Div Dermatol, St Louis, MO 63110 USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Mallory, Susan B.
;
Foglia, Robert P.
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机构:
Childrens Med Ctr Dallas, Dept Pediat Surg, Dallas, TX USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Boucher, W.
;
Stern, J. M.
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Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Stern, J. M.
;
Kotsinyan, V.
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Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Kotsinyan, V.
;
Kempuraj, D.
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机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Kempuraj, D.
;
Papaliodis, D.
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Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Papaliodis, D.
;
Cohen, M. S.
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机构:
Tufts Univ, New England Med Ctr, Boston, MA 02111 USA
Lahey Clin Fdn, Dept Urol, Burlington, MA USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Cohen, M. S.
;
Theoharides, T. C.
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机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
机构:
St Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Washington Univ, Sch Med, St Louis, MO USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Asz, Jose
;
Asz, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Gen Dr Manuel Gea Gonzalez, Dept Dermatol, Mexico City, DF, MexicoSt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Asz, Daniel
;
Moushey, Robin
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Washington Univ, Sch Med, St Louis, MO USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Moushey, Robin
;
Seigel, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Washington Univ, Sch Med, St Louis, MO USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Seigel, Jennifer
;
Mallory, Susan B.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, St Louis, MO USA
St Louis Childrens Hosp, Div Dermatol, St Louis, MO 63110 USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
Mallory, Susan B.
;
Foglia, Robert P.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Med Ctr Dallas, Dept Pediat Surg, Dallas, TX USASt Louis Childrens Hosp, Div Pediat Surg & Pediat Acute Wound Serv, St Louis, MO 63110 USA
机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Boucher, W.
;
Stern, J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Stern, J. M.
;
Kotsinyan, V.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Kotsinyan, V.
;
Kempuraj, D.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Kempuraj, D.
;
Papaliodis, D.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Papaliodis, D.
;
Cohen, M. S.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, New England Med Ctr, Boston, MA 02111 USA
Lahey Clin Fdn, Dept Urol, Burlington, MA USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Cohen, M. S.
;
Theoharides, T. C.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA
Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USATufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USA