Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

被引：25

作者：

Bernstein, Kenneth E. ^{[1
,2
]}

Gonzalez-Villalobos, Romer A. ^{[1
,2
]}

Giani, Jorge F. ^{[1
]}

Shah, Kandarp ^{[1
]}

Bernstein, Ellen ^{[1
]}

Janjulia, Tea ^{[1
]}

Koronyo, Yosef ^{[3
,4
]}

Shi, Peng D. ^{[5
]}

Koronyo-Hamaoui, Maya ^{[1
,3
,4
]}

Fuchs, Sebastien ^{[1
,2
,6
]}

Shen, Xiao Z. ^{[1
,2
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[3] Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA

[4] Maxine Dunitz Neurosurg Res Inst, Los Angeles, CA 90048 USA

[5] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA

[6] Western Univ Hlth Sci, Coll Osteopath Med, Dept Basic Med Sci, Pomona, CA 91766 USA

来源：

BIOLOGICAL CHEMISTRY | 2014年 / 395卷 / 10期

关键词：

ACE; 10/10; Alzheimer disease; macrophages; monocytes; peptidase; BLOOD-PRESSURE; CELLS; RESISTANT; MICE;

D O I：

10.1515/hsz-2013-0295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.

引用

页码：1173 / 1178

页数：6

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