Role of the Microbiota in Immunity and Inflammation

被引：3501

作者：

Belkaid, Yasmine ^{[1
]}

Hand, Timothy W. ^{[1
,2
]}

机构：

[1] NIAID, Immun Barrier Sites Initiat, NIH, Bethesda, MD 20892 USA

[2] NIAID, Parasit Dis Lab, Mucosal Immunol Sect, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2014年 / 157卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; REGULATORY T-CELLS; CHAIN FATTY-ACIDS; INTESTINAL DENDRITIC CELLS; GUT COMMENSAL BACTERIA; LECTIN REGIII-GAMMA; TOLL-LIKE RECEPTORS; GERM-FREE MICE; ORAL TOLERANCE; CROHNS-DISEASE;

D O I：

10.1016/j.cell.2014.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microbiota plays a fundamental role on the induction, training, and function of the host immune system. In return, the immune system has largely evolved as a means to maintain the symbiotic relationship of the host with these highly diverse and evolving microbes. When operating optimally, this immune system-microbiota alliance allows the induction of protective responses to pathogens and the maintenance of regulatory pathways involved in the maintenance of tolerance to innocuous antigens. However, in high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses. This phenomenon is proposed to account for some of the dramatic rise in autoimmune and inflammatory disorders in parts of the world where our symbiotic relationship with the microbiota has been the most affected.

引用

页码：121 / 141

页数：21

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