Effects of exposure to electromagnetic radiation at 835 MHZ on growth, morphology and secretory characteristics of a mast cell analogue, RBL-2H3

被引:35
作者
Donnellan, M
McKenzie, DR
French, PW
机构
[1] ST VINCENTS HOSP, CTR IMMUNOL, SYDNEY, NSW 2010, AUSTRALIA
[2] UNIV SYDNEY, SCH PHYS, DEPT APPL PHYS, SYDNEY, NSW 2006, AUSTRALIA
关键词
electromagnetic fields; cell growth; secretion; cytoskeleton; mast cells;
D O I
10.1006/cbir.1997.0162
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A mast cell line, RBL-2H3, was exposed to 835 MHz for 20 minutes, three times per day for 7 days at a power density of 8.1 +/- 3 mW/cm(2). From day 4 onwards, it was observed that the rate of DNA synthesis and cell replication increased, that actin distribution and cell morphology became altered, and the amount of beta-hexosaminidase (a marker of granule secretion) released in response to a calcium ionophore was significantly enhanced, in comparison to unexposed cultures. There were no effects seen on levels of cytoskeletal protein synthesis or of beta-actin mRNA. Morphological changes persisted following subculture for at least 7 days in the absence of further exposure. It is hypothesized that effects of exposure to an electromagnetic field at 835 MHz may be mediated via a signal transduction pathway. (C) 1997 Academic Press Limited.
引用
收藏
页码:427 / 439
页数:13
相关论文
共 46 条
  • [1] CYTOLOGICAL EFFECTS OF 50-HZ ELECTROMAGNETIC-FIELDS ON HUMAN-LYMPHOCYTES IN-VITRO
    ANTONOPOULOS, A
    YANG, BC
    STAMM, A
    HELLER, WD
    OBE, G
    [J]. MUTATION RESEARCH LETTERS, 1995, 346 (03): : 151 - 157
  • [3] POSSIBLE MECHANISMS OF WEAK ELECTROMAGNETIC-FIELD COUPLING IN BRAIN-TISSUE
    BAWIN, SM
    SHEPPARD, A
    ADEY, WR
    [J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1978, 5 (01): : 67 - 76
  • [4] EVIDENCE FOR DIRECT EFFECT OF MAGNETIC-FIELDS ON NEURITE OUTGROWTH
    BLACKMAN, CF
    BENANE, SG
    HOUSE, DE
    [J]. FASEB JOURNAL, 1993, 7 (09) : 801 - 806
  • [5] CHANGES IN POLYPEPTIDE DISTRIBUTION STIMULATED BY DIFFERENT LEVELS OF ELECTROMAGNETIC AND THERMAL-STRESS
    BLANK, M
    KHORKOVA, O
    GOODMAN, R
    [J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1994, 33 (02): : 109 - 114
  • [6] CORRELATION BETWEEN THE AMPLITUDE OF PLASMA-MEMBRANE FLUCTUATIONS AND THE RESPONSE OF CELLS TO ELECTRIC AND MAGNETIC-FIELDS
    BROUDE, N
    KARABAKHTSIAN, R
    SHALTS, N
    GOODMAN, R
    HENDERSON, AS
    [J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1994, 33 (01): : 19 - 23
  • [7] ALTERATIONS IN PROTEIN-KINASE ACTIVITY FOLLOWING EXPOSURE OF CULTURED HUMAN-LYMPHOCYTES TO MODULATED MICROWAVE FIELDS
    BYUS, CV
    LUNDAK, RL
    FLETCHER, RM
    ADEY, WR
    [J]. BIOELECTROMAGNETICS, 1984, 5 (03) : 341 - 351
  • [8] CELL-CYCLE ALTERATIONS INDUCED BY ISOTHERMAL 27-MHZ RADIOFREQUENCY RADIATION EXPOSURE
    CAO, GH
    LIU, LM
    CLEARY, SF
    [J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1995, 37 (02): : 131 - 140
  • [9] EFFECTS OF RF POWER ABSORPTION IN MAMMALIAN-CELLS
    CLEARY, SF
    LIU, LM
    CAO, GH
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 649 : 166 - 175
  • [10] CUNHAMELO JR, 1989, J IMMUNOL, V143, P2617