Crosstalk of Notch with p53 and p63 in cancer growth control

被引：163

作者：

Dotto, G. Paolo ^{[1
,2
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

[2] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 08期

关键词：

CELL-CYCLE ARREST; NF-KAPPA-B; TUMOR-SUPPRESSOR; FACTOR RECEPTOR; STEM-CELL; SIGNALING PATHWAYS; DOWN-REGULATION; TRANSCRIPTIONAL COACTIVATOR; NEGATIVE REGULATION; PRESENILIN-1; GENE;

D O I：

10.1038/nrc2675

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Understanding the complexity of cancer depends on an elucidation of the underlying regulatory networks, at the cellular and intercellular levels and in their temporal dimension. This Opinion article focuses on the multilevel crosstalk between the Notch pathway and the p53 and p63 pathways. These two coordinated signalling modules are at the interface of external damaging signals and control of stem cell potential and differentiation. Positive or negative reciprocal regulation of the two pathways can vary with cell type and cancer stage. Therefore, selective or combined targeting of the two pathways could improve the efficacy and reduce the toxicity of cancer therapies.

引用

收藏

页码：587 / 595

页数：9

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