Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis

被引：144

作者：

Wang, Lili ^{[1
]}

Li, Yu ^{[1
]}

Guo, Yubo ^{[1
]}

Ma, Rufeng ^{[1
]}

Fu, Min ^{[3
]}

Niu, Jianzhao ^{[1
]}

Gao, Sihua ^{[2
]}

Zhang, Dongwei ^{[2
]}

机构：

[1] Beijing Univ Chinese Med, Preclin Med Sch, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Diabet Res Ctr, Beijing 100029, Peoples R China

[3] McGill Univ, Ctr Hlth, Montreal, PQ H4A 3J1, Canada

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Herba epimedii; Chinese medicine; clinical trials; phytochemistry; pharmacology; osteoporosis; MARROW STROMAL CELLS; DEPENDENT OSTEOBLASTIC FUNCTIONS; MESENCHYMAL STEM-CELLS; OSTEOGENIC DIFFERENTIATION; BONE-RESORPTION; IN-VITRO; TOTAL FLAVONOIDS; BREVICORNUM MAXIM; ICARIIN PROTECTS; CBFA1; EXPRESSION;

D O I：

10.2174/1381612822666151112145907

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Herba Epimedii (HEP) known as YinYangHuo in Chinese is the dried leaf of the Epimediium, and has been historically used in combination with other herbs to treat skeletal diseases in traditional Chinese medicine (TCM). Here, we review the historical TCM interpretation of the action of HEP, its use in clinical trials, its main phytochemical constituents and its pharmacological findings. 85 clinical trials were identified which used HEP in TCM prescriptions with other herbs to treat primary and secondary osteoporosis from 2005 to now. More than 60 individual compounds were isolated and characterized from HEP and studied in various animal and cell models. HEP and its constituents exhibited a variety of anti-resorptive and bone formation-stimulating effects, which target different pathways in the bone remodeling cycle. These compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-osteoporotic drugs. These approaches are also useful for guiding our research to employ an integrative therapeutic approach to treat complex diseases such as osteoporosis diseases which could be superior to the conventional single target - single drug approach.

引用

页码：328 / 349

页数：22

共 145 条

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[2]

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[4]

Bao Jia-rong, 2005, Wei Sheng Yan Jiu, V34, P191