N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation

被引：58

作者：

Ringdén, O

Remberger, M

Lehmann, S

Hentschke, P

Mattsson, J

Klaesson, S

Aschan, J

机构：

[1] Karolinska Inst, Huddinge Hosp, Dept Clin Immunol, SE-14186 Huddinge, Sweden

[2] Karolinska Inst, Huddinge Hosp, Ctr Allogene Stem Cell Transplantat, Huddinge, Sweden

[3] Karolinska Inst, Huddinge Hosp, Dept Hematol, Huddinge, Sweden

[4] Karolinska Inst, Huddinge Hosp, Dept Paediat, Huddinge, Sweden

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / 09期

关键词：

allogeneic stem cell transplantation; veno-occlusive disease of the liver; N-acetylcysteine; cytokines;

D O I：

10.1038/sj.bmt.1702387

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Three patients developed veno-occlusive disease of the liver (VOD) after allogeneic stem cell transplantation. On the day after diagnosis, N-acetylcysteine (NAC) was given, initially in loading doses and thereafter 50-150 mg/kg/day for 12 to 31 days. The maximum bilirubin levels were 137, 58 and 138 mmol/l in the three patients, respectively. After the introduction of NAG, bilirubin, aspertate aminotransferase, sIL-2 receptor and IL-8 decreased. All three patients achieved normal bilirubin levels and prothrombin times. To conclude, NAC may be useful for treatment of VOD.

引用

页码：993 / 996

页数：4

共 13 条

[1]

BONANOMI L, 1980, EUR J RESPIR DIS, V61, P45

[2]

COLOMBO AA, 1994, BLOOD, V84, pA511

[3]

Hagglund H, 1996, TRANSPLANTATION, V62, P1076

[4] Norethisterone treatment, a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation [J].

Hägglund, H ;

Remberger, M ;

Klaesson, S ;

Lönnqvist, B ;

Ljungman, P ;

Ringdén, O .

BLOOD, 1998, 92 (12) :4568-4572

[5] IMPROVED OUTCOME OF PARACETAMOL-INDUCED FULMINANT HEPATIC-FAILURE BY LATE ADMINISTRATION OF ACETYLCYSTEINE [J].

HARRISON, PM ;

KEAYS, R ;

BRAY, GP ;

ALEXANDER, GJM ;

WILLIAMS, R .

LANCET, 1990, 335 (8705) :1572-1573

[6]

HOLLER E, 1990, BLOOD, V75, P1011

[7] VENOOCCLUSIVE DISEASE OF THE LIVER FOLLOWING BONE-MARROW TRANSPLANTATION [J].

JONES, RJ ;

LEE, KSK ;

BESCHORNER, WE ;

VOGEL, VG ;

GROCHOW, LB ;

BRAINE, HG ;

VOGELSANG, GB ;

SENSENBRENNER, LL ;

SANTOS, GW ;

SARAL, R .

TRANSPLANTATION, 1987, 44 (06) :778-783

[8]

Remberger M, 1995, TRANSPLANTATION, V60, P1293

[9]

Remberger M, 1997, EUR J HAEMATOL, V59, P254

[10]

RINGDEN O, 1995, BONE MARROW TRANSPL, V15, P619

← 1 2 →