Protein folding as a diffusional process

被引:94
作者
Jacob, M [1 ]
Schmid, FX [1 ]
机构
[1] Univ Bayreuth, Biochem Lab, D-95440 Bayreuth, Germany
关键词
D O I
10.1021/bi991503o
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A protein chain must move relative to the solvent molecules and explore many conformations when it folds from the extended unfolded state to the compact native state. Experimental and theoretical approaches suggest that diffusional processes in fact contribute to the kinetics of protein folding. We describe here how variations of the solvent viscosity can be employed to uncover the diffusional contributions to a folding reaction and assess the use of transition state theory and Kramers' rate theory for the analysis of protein folding reactions.
引用
收藏
页码:13773 / 13779
页数:7
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