Microbial carboxyl esterases: classification, properties and application in biocatalysis

被引：326

作者：

Bornscheuer, UT ^{[1
]}

机构：

[1] Univ Greifswald, Dept Tech Chem & Biotechnol, Inst Chem & Biochem, D-17487 Greifswald, Germany

来源：

FEMS MICROBIOLOGY REVIEWS | 2002年 / 26卷 / 01期

关键词：

carboxyl esterase; microbial; biocatalysis; organic synthesis; directed evolution;

D O I：

10.1016/S0168-6445(01)00075-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Esterases (EC 3.1.1.x) represent a diverse group of hydrolases catalyzing the cleavage and formation of ester bonds and are widely distributed in animals, plants and micro organisms. Beside lipases, a considerable number of microbial carboxyl esterases have also been discovered and overexpressed. This review summarizes their properties and classification. Special emphasis is given on their application in organic synthesis for the resolution of racemates and prostereogenic compounds. In addition, recent results for altering their properties by directed evolution are presented. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：73 / 81

页数：9

共 83 条

[1]

AMAKI Y, 1994, APPL MICROBIOL BIOT, V40, P664, DOI 10.1007/s002530050047

[2] PURIFICATION AND PROPERTIES OF A THERMOSTABLE ESTERASE OF BACILLUS-STEAROTHERMOPHILUS PRODUCED BY RECOMBINANT BACILLUS-BREVIS [J].

AMAKI, Y ;

TULIN, EE ;

UEDA, S ;

OHMIYA, K ;

YAMANE, T .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992, 56 (02) :238-241

[3]

Arnold F H, 1997, Adv Biochem Eng Biotechnol, V58, P1

[4] Directed evolution of biocatalysts [J].

Arnold, FH ;

Volkov, AA .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (01) :54-59

[5] Design by directed evolution [J].

Arnold, FH .

ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (03) :125-131

[6]

ARNOLD FH, 1999, ENG SCI, P40

[7] Bacterial lipolytic enzymes: classification and properties [J].

Arpigny, JL ;

Jaeger, KE .

BIOCHEMICAL JOURNAL, 1999, 343 :177-183

[8]

AZZOLINA O, 1995, FARMACO, V50, P221

[9]

AZZOLINA O, 1995, FARMACO, V50, P725

[10] Rapid screening of hydrolases for the enantioselective conversion of 'difficult-to-resolve' substrates [J].

Baumann, M ;

Hauer, BH ;

Bornscheuer, UT .

TETRAHEDRON-ASYMMETRY, 2000, 11 (23) :4781-4790

← 1 2 3 4 5 6 7 8 9 →