Cooperative metal-coordination and ion pairing in tripeptide recognition

被引：67

作者：

Wright, AT ^{[1
]}

Anslyn, EV ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

关键词：

D O I：

10.1021/ol036441f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The recognition of tripeptides by a metal-centered receptor consisting of a rigid backbone region and variable tripeptide arms is described. The studies showed that the receptor was selective for L-Xxx-L-Lys-L-Lys, with Xxx = His, Cys, and Met, giving association constants near 1.0 x 10(5) M-1. Binding enhancement through cooperative interactions of the peptidic arms is demonstrated.

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页码：1341 / 1344

页数：4

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