Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias

被引：46

作者：

Vos, MA ^{[1
]}

van Opstal, JM ^{[1
]}

Leunissen, JDM ^{[1
]}

Verduyn, SC ^{[1
]}

机构：

[1] Acad Hosp Maastricht, Cardiovasc Res Inst Maasticht, Dept Cardiol, NL-6202 AZ Maastricht, Netherlands

来源：

PHARMACOLOGY & THERAPEUTICS | 2001年 / 92卷 / 2-3期

关键词：

acquired long-QT syndrome; dispersion of repolarization; sudden cardiac death; antiarrhythmic drugs; ventricular arrhythmias;

D O I：

10.1016/S0163-7258(01)00162-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

When a new (cardiovascular) drug shows signs of QT interval prolongation on the ECG (delay in repolarization time), the regulatory agencies demand screening of its possible proarrhythmic potential before approving it for clinical practice. In this review, identified predisposing factors have been related to specific electrophysiological parameters, allowing quantification of their contribution to Torsade de Pointes arrhythmias, In addition, arrhythmogenic mechanisms involved in the initiation and perpetuation of drug-induced Torsade de Pointes are discussed. (C) 2001 Elsevier Science Inc. All rights reserved.

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收藏

页码：109 / 122

页数：14

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