Comparing antibody and small-molecule therapies for cancer

被引：623

作者：

Imai, Kohzoh

Takaoka, Akinori

机构：

[1] Sapporo Med Univ, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

[2] Univ Tokyo, Fac Med, Grad Sch Med, Dept Immunol,Bunkyo Ku, Tokyo 1130033, Japan

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 09期

关键词：

D O I：

10.1038/nrc1913

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 'magic bullet' concept of specifically targeting cancer cells at the same time as sparing normal tissues is now proven, as several monoclonal antibodies and targeted small-molecule compounds have been approved for cancer treatment. Both antibodies and small-molecule compounds are therefore promising tools for target-protein-based cancer therapy. We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy.

引用

页码：714 / 727

页数：14

共 163 条

[1] Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer [J].

Agus, DB ;

Gordon, MS ;

Taylor, C ;

Natale, RB ;

Karlan, B ;

Mendelson, DS ;

Press, MF ;

Allison, DE ;

Sliwkowski, MX ;

Lieberman, G ;

Kelsey, SM ;

Fyfe, G .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (11) :2534-2543

[2]

Amann J, 2005, CANCER RES, V65, P226

[3]

[Anonymous], NAT REV DRUG DISC SU

[4] Role of tyrosine kinase inhibitors in cancer therapy [J].

Arora, A ;

Scholar, EM .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 315 (03) :971-979

[5]

Arteaga CL, 2003, CLIN CANCER RES, V9, P1579

[6]

Bailey L. Renee, 2003, Proceedings of the American Association for Cancer Research Annual Meeting, V44, P1362

[7] Upping the ante on antibodies [J].

Baker, M .

NATURE BIOTECHNOLOGY, 2005, 23 (09) :1065-1072

[8] Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin [J].

Baselga, J ;

Pfister, D ;

Cooper, MR ;

Cohen, R ;

Burtness, B ;

Bos, M ;

D'Andrea, G ;

Seidman, A ;

Norton, L ;

Gunnett, K ;

Falcey, J ;

Anderson, V ;

Waksal, H ;

Mendelsohn, J .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (04) :904-914

[9]

Baselga J, 2001, EUR J CANCER, V37, pS16

[10]

Baselga J, 1998, CANCER RES, V58, P2825

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