1α,25-Dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in Human Monocytes

被引：172

作者：

Almerighi, Cristiana ^{[3
]}

Sinistro, Anna ^{[1
]}

Cavazza, Antonella ^{[2
]}

Ciaprini, Chiara ^{[3
]}

Rocchi, Giovanni ^{[1
]}

Bergamini, Alberto ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Publ Hlth & Cellular Biol, I-00133 Rome, Italy

[2] Univ Parma, Dept Analyt Chem, I-43100 Parma, Italy

[3] Univ Roma Tor Vergata, Dept Internal Med, I-00133 Rome, Italy

来源：

CYTOKINE | 2009年 / 45卷 / 03期

关键词：

CD40L; 1; alpha; 25-Dihydroxyvitamin D-3; Cytokine; Monocyte; T cell; SOLUBLE CD40 LIGAND; CD4(+) T-CELLS; VITAMIN-D INTAKE; ANTIGEN-EXPRESSION; DEATH APOPTOSIS; TH2; CLONES; ACTIVATION; INDUCTION; RESPONSES; LIGATION;

D O I：

10.1016/j.cyto.2008.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD40 ligand (CD40L) stimulation induces proinflammatory and immunomodulatory activity in monocytes. Here, we report on the effects of the steroid hormone 1 alpha,25-dihydroxyvitamin D3 (1,25133) on human blood monocytes that have been stimulated with the CD40L ligand. Co-treatment of CD40L-stimulated monocytes with 1,25D3 resulted in reduced production and secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta, as well as in reduced expression of the surface co-stimulatory molecules CD80 and CD86. In addition, costimulation of CD4+ T lymphocytes by monocytes co-treated with CD40L and 1,25D3 resulted in reduced cell proliferation and diminished interferon (IFN)-gamma but enhanced IL-10 production by CD4+ T cells. Finally, 1,25D3 interfered with the ability of CD40L to rescue monocytes from apoptosis induced by serum withdrawal. These findings suggest that 1,25D3 may regulate the interaction of monocytes with T cells or other cell types that express CD40L, thus influencing the outcome of the immune or inflammatory response. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：190 / 197

页数：8

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