Hypopigmented mycosis fungoides: Treatment and a 6 1/2-year follow-up of 9 patients

被引:55
作者
Akaraphanth, R
Douglass, MC
Lim, HW
机构
[1] Henry Ford Hlth Syst, Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA
[2] Inst Dermatol, Bangkok, Thailand
关键词
D O I
10.1016/S0190-9622(00)90006-9
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: The clinical course of hypopigmented mycosis fungoides has not been well described. Objective and Methods: We sought to review the management and follow-up of patients with hypopigmented mycosis fungoides evaluated between January 1990 and August 1998. Results: There were 7 African American and 2 Asian patients (5 male and 4 female patients); 8 had stage Ia and I had stage Ib disease. The mean age at diagnosis was 34.4 years, the mean latent period was 9.2 years, and the mean follow-up period after diagnosis was 6.5 years. Treatment modalities used included psoralen WA, WE, and topical mechlorethamine. Eight had complete clinical responses, and another had a partial response. The remission period ranged from 2 months to 3 years. In all but one patient, lesions recurred; all responded rapidly to another course of therapy. Conclusion: Hypopigmented mycosis fungoides is characterized by early onset, occurrence in dark-skinned individuals, and good response to therapy. Recurrences are common. In most, it has a biologically benign course.
引用
收藏
页码:33 / 39
页数:7
相关论文
共 21 条
[1]  
Amichai Boaz, 1996, Journal of Dermatology (Tokyo), V23, P425
[2]   PROGRESSION OF PIGMENTED PURPURA-LIKE ERUPTIONS TO MYCOSIS-FUNGOIDES - REPORT OF 3 CASES [J].
BARNHILL, RL ;
BRAVERMAN, IM .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1988, 19 (01) :25-31
[3]  
BREATHNACH SM, 1982, BRIT J DERMATOL, V106, P643, DOI 10.1111/j.1365-2133.1982.tb11678.x
[4]  
BUNN PA, 1979, CANCER TREAT REP, V63, P725
[5]  
COOPER D, 1992, ARCH DERMATOL, V128, P1265
[6]   UNUSUAL CLINICAL PRESENTATION OF EPIDERMOTROPIC CUTANEOUS LYMPHOMA - SMALL HYPOPIGMENTED MACULES [J].
DABSKI, K ;
STOLL, HL ;
MILGROM, H .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 1985, 24 (02) :108-115
[7]   HYPOPIGMENTED MYCOSIS-FUNGOIDES - SPECULATIONS ABOUT THE MECHANISM OF HYPOPIGMENTATION [J].
GOLDBERG, DJ ;
SCHINELLA, RS ;
KECHIJIAN, P .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1986, 8 (04) :326-330
[8]   HYPOPIGMENTED MYCOSIS-FUNGOIDES [J].
HANDFIELDJONES, SE ;
SMITH, NP ;
BREATHNACH, SM .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1992, 17 (05) :374-375
[9]  
HEALD PW, 1993, DERMATOLOGY GEN MED, P1285
[10]  
HOSHY KE, 1995, J DERMATOL, V22, P424