Therapeutic Neovascularization by the Implantation of Autologous Mononuclear Cells in Patients with Connective Tissue Diseases

被引：19

作者：

Takahashi, Masafumi ^{[1
,2
]}

Izawa, Atsushi ^{[2
]}

Ishigatsubo, Yoshiaki ^{[3
]}

Fujimoto, Kazuteru ^{[4
]}

Miyamoto, Masaaki ^{[5
]}

Horie, Takashi ^{[6
]}

Aizawa, Yoshifusa ^{[7
]}

Amano, Jun ^{[8
]}

Minota, Seiji

Murohara, Toyoaki ^{[9
]}

Matsubara, Hiroaki ^{[10
]}

Ikeda, Uichi ^{[2
]}

机构：

[1] Jichi Med Univ, Ctr Mol Med, Shimotsuke, Tochigi 3290498, Japan

[2] Shinshu Univ, Grad Sch Med, Dept Cardiovasc Med, Matsumoto, Nagano, Japan

[3] Yokohama City Univ, Grad Sch Med, Yokohama, Kanagawa, Japan

[4] Natl Hosp Org, Kumamoto Med Ctr, Kumamoto, Japan

[5] Nippon Med Sch, Tokyo, Japan

[6] Sapporo Hokuyu Hosp, Sapporo, Hokkaido, Japan

[7] Niigata Univ, Grad Sch Med, Niigata 95021, Japan

[8] Shinshu Univ, Sch Med, Matsumoto, Nagano, Japan

[9] Nagoya Univ, Grad Sch Med, Nagoya, Aichi 4648601, Japan

[10] Kyoto Prefectural Univ, Grad Sch Med, Kyoto, Japan

来源：

CURRENT PHARMACEUTICAL DESIGN | 2009年 / 15卷 / 24期

关键词：

Angiogenesis; mononuclear cells; connective tissue disease; EPCs; ischemia; scleroderma; vasculopathy; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW; PERIPHERAL-BLOOD; CYCLOPENTENONE PROSTAGLANDINS; ISCHEMIC DIGITS; LIMB ISCHEMIA; GENE-TRANSFER; ANGIOGENESIS; LUPUS; TRANSPLANTATION;

D O I：

10.2174/138161209788923813

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vasculopathy in patients with connective tissue diseases (CTDs), including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), is a serious complication that mainly affects small arteries and capillaries, reduces the blood flow and causes progressive tissue ischemia. Recently, CTD patients have been reported to have abnormalities in circulating endothelial progenitor cells (EPCs); these abnormalities are believed to contribute to the pathophysiology of vasculopathy and to the premature and accelerated development of atherosclerosis in CTD patients. Furthermore, we are currently conducting a clinical pilot study to determine the efficacy of implanting autologous mononuclear cells obtained from the bone marrow and peripheral blood into the ischemic digits or limbs of CTD patients. In this review, we discuss the role of EPCs in the process of neovascularization and in the pathophysiology of CTDs, and we describe a clinical pilot study on the use of autologous cell therapy for treating ischemic digits in patients with CTDs.

引用

页码：2778 / 2783

页数：6

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