Nephron Mass and Cardiovascular and Renal Disease Risks

被引：38

作者：

Abitbol, Carolyn L. ^{[1
]}

Ingelfinger, Julie R. ^{[2
]}

机构：

[1] Univ Miami, Div Pediat Nephrol, Miami, FL 33101 USA

[2] New England Journal Med, Boston, MA USA

来源：

SEMINARS IN NEPHROLOGY | 2009年 / 29卷 / 04期

关键词：

Developmental origins; perinatal; renal endowment; nephrogenesis; RENIN-ANGIOTENSIN SYSTEM; INTRAUTERINE GROWTH-RETARDATION; BIRTH-WEIGHT; BLOOD-PRESSURE; GLOMERULAR NUMBER; FOLLOW-UP; BRANCHING MORPHOGENESIS; PROTEIN RESTRICTION; INCREASED APOPTOSIS; ADULT HYPERTENSION;

D O I：

10.1016/j.semnephrol.2009.03.019

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

The nephron endowment begins with the complex process of nephrogenesis, which is controlled through genetic and environmental influences from preconception up until approximately 36 weeks of gestation. The total number of nephrons in human beings averages about 1 million per kidney but varies up to 10-fold, from approximately 200,000 to more than 2 million. Low nephron mass is associated with the development of hypertension and, in some ethnic populations, the concurrence of cardiovascular and renal disease risks in later life. Kidney size and nephron number also are related directly to birth weight with persons born preterm or with evidence of intrauterine growth restriction more likely to develop certain diseases in later life. © 2009 Elsevier Inc. All rights reserved.

引用

页码：445 / 454

页数：10

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