Heads or tails:: Host-parasite interactions in the Drosophila-Wolbachia system

被引:114
作者
Veneti, Z
Clark, ME
Karr, TL
Savakis, C
Bourtzis, K
机构
[1] Univ Ioannina, Dept Environm & Nat Resources Management, Agrinion 30100, Greece
[2] FORTH, Inst Mol Biol & Biotechnol, Iraklion, Greece
[3] Univ Crete, Sch Med, Iraklion, Greece
[4] Univ Chicago, Dept Organismal Biol & Anat, Chicago, IL 60637 USA
关键词
D O I
10.1128/AEM.70.9.5366-5372.2004
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Wolbachia strains are endosymbiotic bacteria typically found in the reproductive tracts of arthropods. These bacteria manipulate host reproduction to ensure maternal transmission. They are usually transmitted vertically, so it has been predicted that they have evolved a mechanism to target the host's germ cells during development. Through cytological analysis we found that Wolbachia strains display various affinities for the germ line of Drosophila. Different Wolbachia strains show posterior, anterior, or cortical localization in Drosophild embryos, and this localization is congruent with the classification of the organisms based on the wsp (Wolbachia surface protein) gene sequence. This embryonic distribution pattern is established during early oogenesis and does not change until late stages of embryogenesis. The posterior and anterior localization of Wolbachia resembles that of oskar and bicoid mRNAs, respectively, which define the anterior-posterior axis in the Drosophila oocyte. By comparing the properties of a single Wolbachia strain in different host backgrounds and the properties of different Wolbachia strains in the same host background, we concluded that bacterial factors determine distribution, while bacterial density seems to be limited by the host. Possible implications concerning cytoplasmic incompatibility and evolution of strains are discussed.
引用
收藏
页码:5366 / 5372
页数:7
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