The role of motility as a virulence factor in bacteria

被引：525

作者：

Josenhans, C ^{[1
]}

Suerbaum, S ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Hyg & Microbiol, D-97080 Wurzburg, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2002年 / 291卷 / 08期

关键词：

virulence; motility; flagella; pathogenic bacteria; type III secretion systems; animal models;

D O I：

10.1078/1438-4221-00173

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Many bacteria that cause diseases of humans, animals and plants use flagella to move. This review summarises recent studies that have analysed the role of motility and chemotaxis in the host-parasite relationship of pathogenic bacteria. These studies have shown that for many pathogens, motility is essential in some phases of their life cycle and that virulence and motility are often intimately linked by complex regulatory networks. Possibilities to exploit bacterial motility as a specific therapeutic antibacterial target to cure or prevent disease are discussed.

引用

页码：605 / 614

页数：10

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