Mammalian epididymal proteome

被引:95
作者
Dacheux, Jean-Louis [1 ]
Belleannee, Clemence [1 ]
Jones, Russell [2 ]
Labas, Valerie [3 ]
Belghazi, Maya [3 ]
Guyonnet, Benoit [1 ]
Druart, Xavier [1 ]
Gatti, Jean Luc [1 ]
Dacheux, Francoise [1 ]
机构
[1] INRA, CNRS 6175, F-37380 Nouzilly, France
[2] Univ Newcastle, Newcastle, NSW 2308, Australia
[3] INRA, Serv Spectrometrie Masse Prote, F-37380 Nouzilly, France
关键词
Proteome; Secretome; Epididymis; Sperm maturation; I-CONVERTING-ENZYME; PRION PROTEIN; SPERM PROTEIN; FLUID; SPERMATOZOA; MATURATION; SECRETION; BOAR; RAT; IDENTIFICATION;
D O I
10.1016/j.mce.2009.03.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between several mammals could be an informative approach to finding common sperm modifications which are not species-specific. The new global biological approaches such as transcriptomes and proteomes provide considerable information which can be used for such comparative approaches. This report summarizes our proteomic studies of the epididymis of several mammals, including humans. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:45 / 50
页数:6
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