Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

被引：206

作者：

Duits, Flora H. ^{[1
,2
]}

Martinez-Lage, Pablo ^{[3
]}

Paquet, Claire ^{[4
,5
,6
]}

Engelborghs, Sebastiaan ^{[7
,8
]}

Lleo, Alberto ^{[9
,10
]}

Hausner, Lucrezia ^{[11
]}

Molinuevo, Jose L. ^{[12
,13
]}

Stomrud, Erik ^{[14
]}

Farotti, Lucia ^{[15
]}

Ramakers, Inez H. G. B. ^{[16
]}

Tsolaki, Magda ^{[17
]}

Skarsgard, Constance ^{[18
]}

Astrand, Ragnar ^{[19
]}

Wallin, Anders ^{[20
]}

Vyhnalek, Martin ^{[21
,22
,23
]}

Holmber-Clausen, Marie ^{[24
]}

Forlenza, Orestes V. ^{[25
]}

Ghezzi, Laura ^{[26
]}

Ingelsson, Martin ^{[27
]}

Hoff, Erik I. ^{[28
]}

Roks, Gerwin ^{[29
]}

de Mendonca, Alexandre ^{[30
]}

Papma, Janne M. ^{[31
]}

Izagirre, Andrea ^{[3
]}

Taga, Mariko ^{[4
,5
,6
]}

Struyfs, Hanne ^{[7
]}

Alcolea, Daniel A. ^{[9
,10
]}

Froelich, Lutz ^{[11
]}

Balasa, Mircea ^{[12
,13
]}

Minthon, Lennart ^{[14
]}

Twisk, Jos W. R. ^{[32
]}

Persson, Staffan ^{[33
]}

Zetterberg, Henrik ^{[33
,34
]}

van der Flier, Wiesje M. ^{[1
,2
,32
]}

Teunissen, Charlotte E. ^{[35
]}

Scheltens, Philip ^{[1
,2
]}

Blennow, Kaj ^{[33
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[3] Alzheimer Fdn, Fdn CITA, Dept Neurol, San Sebastian, Spain

[4] INSERM, U942, F-75654 Paris 13, France

[5] Univ Paris Diderot, Sorbonne Paris Cite, UMRS 942, Paris, France

[6] Hop Lariboisiere, AP HP, Res Memory Ctr Paris North, F-75475 Paris, France

[7] Univ Antwerp, Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, B-2020 Antwerp, Belgium

[8] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol & Memory Clin, Antwerp, Belgium

[9] Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain

[10] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain

[11] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Heidelberg, Germany

[12] ICN Hosp Clin & Univ, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

[13] Pasqual Maragall Fdn, Barcelona, Spain

[14] Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden

[15] Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, I-06100 Perugia, Italy

[16] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, NL-6200 MD Maastricht, Netherlands

[17] Aristotle Univ Thessaloniki, Dept Neurol 3, Skopje, North Macedonia

[18] Kalmar Cty Hosp, Dept Geriatr, Kalmar, Sweden

[19] Karlstad Cent Hosp, Dept Cognit Med, Karlstad, Sweden

[20] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Memory Clin,Dept Neuropsychiat,Sahlgrenska Univ H, Molndal, Sweden

[21] Charles Univ Prague, Fac Med 2, Dept Neurol, Memory Clin, Prague, Czech Republic

[22] Motol Univ Hosp, Prague, Czech Republic

[23] St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic

[24] Minnesmottagningen, Dept Geriatr, Eskilstuna, Sweden

[25] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil

[26] Univ Milan, Fdn Ca Grandam IRCCS Osped Policlin, Dept Pathophysiol & Transplantat, Neurol Unit, Milan, Italy

[27] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden

[28] Atrium Med Ctr Parkstad, Dept Neurol, Heerlen, Netherlands

[29] St Elizabeth Hosp, Dept Neurol, Tilburg, Netherlands

[30] Univ Lisbon, Fac Med, Dept Mol Med, P-1699 Lisbon, Portugal

[31] Erasmus MC Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands

[32] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[33] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurochem, Molndal, Sweden

[34] UCL Inst Neurol, Dept Mol Neurosci, London, England

[35] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Neurochem Lab & Biobank, Neurosci Campus Amsterdam, Amsterdam, Netherlands

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 02期

基金：

巴西圣保罗研究基金会; 瑞典研究理事会;

关键词：

Lumbar puncture; Cognitive disorders; Alzheimer's disease; Memory clinic; Post-LP complications; Post-LP headache; Multicenter study on LP feasibility; CEREBROSPINAL-FLUID BIOMARKERS; ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DOUBLE-BLIND; HEADACHE; DISEASE; NEEDLE; DEMENTIA; RECOMMENDATIONS;

D O I：

10.1016/j.jalz.2015.08.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：154 / 163

页数：10

共 30 条

[1]

The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[2]

Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A Multicenter Study in Spain [J].

Alcolea, Daniel ;

Martinez-Lage, Pablo ;

Izagirre, Andrea ;

Clerigue, Montserrat ;

Carmona-Iragui, Maria ;

Alvarez, Rosa Maria ;

Fortea, Juan ;

Balasa, Mircea ;

Morenas-Rodriguez, Estrella ;

Llado, Albert ;

Grau, Oriol ;

Blennow, Kaj ;

Lleo, Alberto ;

Molinuevo, Jose L. .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 39 (04) :719-726

[3]

Posture and fluids for preventing post-dural puncture headache [J].

Arevalo-Rodriguez, Ingrid ;

Ciapponi, Agustin ;

Munoz, Luis ;

Roque i Figuls, Marta ;

Bonfill Cosp, Xavier .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2013, (07)

[4]

The International Classification of Headache Disorders, 3rd edition (beta version) [J].

Bes, Andre ;

Kunkel, Robert ;

Lance, James W. ;

Nappi, Giuseppe ;

Pfaffenrath, Volker ;

Rose, Frank Clifford ;

Schoenberg, Bruce S. ;

Soyka, Dieter ;

Tfelt-Hansen, Peer ;

Welch, K. Michael A. ;

Wilkinson, Marica ;

Olesen, Jes ;

Bousser, Marie-Germaine ;

Diener, Hans-Christoph ;

Dodick, David ;

First, Michael ;

Goadsby, Peter J. ;

Goebel, Hartmut ;

Lainez, Miguel J. A. ;

Lance, James W. ;

Lipton, Richard B. ;

Nappi, Giuseppe ;

Sakai, Fumihiko ;

Schoenen, Jean ;

Silberstein, Stephen D. ;

Steiner, Timothy J. ;

Olesen, Jes ;

Bendtsen, Lars ;

Dodick, David ;

Ducros, Anne ;

Evers, Stefan ;

First, Michael ;

Goadsby, Peter J. ;

Hershey, Andrew ;

Katsarava, Zaza ;

Levin, Morris ;

Pascual, Julio ;

Russell, Michael B. ;

Schwedt, Todd ;

Steiner, Timothy J. ;

Tassorelli, Cristina ;

Terwindt, Gisela M. ;

Vincent, Maurice ;

Wang, Shuu-Jiun ;

Olesen, J. ;

Evers, S. ;

Charles, A. ;

Hershey, A. ;

Lipton, R. ;

First, M. .

CEPHALALGIA, 2013, 33 (09) :629-808

[5]

BLENNOW K, 1993, ACTA NEUROL SCAND, V88, P221

[6]

Alzheimer's disease [J].

Scheltens, Philip ;

De Strooper, Bart ;

Kivipelto, Miia ;

Holstege, Henne ;

Chetelat, Gael ;

Teunissen, Charlotte E. ;

Cummings, Jeffrey ;

van der Flier, Wiesje M. .

LANCET, 2021, 397 (10284) :1577-1590

[7]

Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease [J].

Blennow, Kaj ;

Dubois, Bruno ;

Fagan, Anne M. ;

Lewczuk, Piotr ;

de Leon, Mony J. ;

Hampel, Harald .

ALZHEIMERS & DEMENTIA, 2015, 11 (01) :58-69

[8]

Sensory and motor thresholds of transcutaneous electrical stimulation are influenced by gender and age [J].

de Jesus Guirro, Rinaldo Roberto ;

de Oliveira Guirro, Elaine Caldeira ;

Alves de Sousa, Natanael Teixeira .

PM&R, 2015, 7 (01) :42-47

[9]

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Hampel, Harald ;

Molinuevo, Jose Luis ;

Blennow, Kaj ;

Dekosky, Steven T. ;

Gauthier, Serge ;

Selkoe, Dennis ;

Bateman, Randall ;

Cappa, Stefano ;

Crutch, Sebastian ;

Engelborghs, Sebastiaan ;

Frisoni, Giovanni B. ;

Fox, Nick C. ;

Galasko, Douglas ;

Habert, Marie-Odile ;

Jicha, Gregory A. ;

Nordberg, Agneta ;

Pasquier, Florence ;

Rabinovici, Gil ;

Robert, Philippe ;

Rowe, Christopher ;

Salloway, Stephen ;

Sarazin, Marie ;

Epelbaum, Stephane ;

de Souza, Leonardo C. ;

Vellas, Bruno ;

Visser, Pieter J. ;

Schneider, Lon ;

Stern, Yaakov ;

Scheltens, Philip ;

Cummings, Jeffrey L. .

LANCET NEUROLOGY, 2014, 13 (06) :614-629

[10]

Diagnostic impact of CSF biomarkers for Alzheimer's disease in a tertiary memory clinic [J].

Duits, Flora H. ;

Prins, Niels D. ;

Lemstra, Afina W. ;

Pijnenburg, Yolande A. L. ;

Bouwman, Femke H. ;

Teunissen, Charlotte E. ;

Scheltens, Philip ;

van der Flier, Wiesje M. .

ALZHEIMERS & DEMENTIA, 2015, 11 (05) :523-532

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