Selected polysaccharides at comparison for their mucoadhesiveness and effect on precorneal residence of different drugs in the rabbit model

被引：45

作者：

Di Colo, Giacomo ^{[1
]}

Zambito, Ylenia ^{[1
]}

Zaino, Chiara ^{[1
]}

Sanso, Marco ^{[2
]}

机构：

[1] Univ Pisa, Dept Bioorgan Chem & Biopharmaceut, I-56126 Pisa, Italy

[2] Farmigea SpA, Pisa, Italy

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2009年 / 35卷 / 08期

关键词：

Corneal contact time; diclofenac; eyedrops; ketotifen; precorneal residence; mucoadhesive polysaccharide; IN-VITRO EVALUATION; OPHTHALMIC VEHICLES; OCULAR EVALUATION; BIOAVAILABILITY; TROPICAMIDE; DELIVERY; HUMANS; EYE;

D O I：

10.1080/03639040802713460

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Mucoadhesive polysaccharides may prolong the residence of ophthalmic drugs in precorneal area. In this article, the mucoadhesiveness of arabinogalactan, tamarind seed polysaccharide, hyaluronan, hydroxyethylcellulose is compared in vivo, by the polymer residence time in rabbit tear fluid, and in vitro, by the polymer-induced increase of viscosity of a mucin dispersion. Polymer residence is prolonged by increased viscosity but shortened by reflex tearing caused by excessive viscosity. Tamarind seed polysaccharide is the most effective in prolonging the residence of ketotifen and diclofenac in precorneal area; hence, it is the optimal eyedrop additive as it is mucoadhesive while not increasing viscosity excessively.

引用

页码：941 / 949

页数：9

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