Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1 independent pathway

被引：18

作者：

Kumar, S

Chaturvedi, NK

Nishi, M

Kawata, M

Tyagi, RK ^{[1
]}

机构：

[1] Jawaharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India

[2] Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kyoto 6028566, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1691卷 / 2-3期

关键词：

nuclear import; nuclear export; leptomycin; steroid receptor;

D O I：

10.1016/j.bbamcr.2004.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleocytoplasmic transport processes are mediated by soluble transport factors constantly navigating between nuclear and cytoplasmic compartments. Our understanding about nuclear export of general 'nuclear import factors' that deliver the cargo to the nucleus is still fragmentary. Utilizing green fluorescent protein tagged glucocorticoid receptor (GR) and relA as our working model and with judicious use of LMB, we show in living cells that all the soluble components of the nuclear import machinery exit nucleus via exportin1/CRM1 independent pathway(s). (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：73 / 77

页数：5

共 18 条

[1] Signaling molecules of the NF-κB pathway shuttle constitutively between cytoplasm and nucleus [J].