Synthesis and biological evaluation of furano-epothilone C

被引：16

作者：

Schinzer, D

Böhm, OM

Altmann, KH

Wartmann, M

机构：

[1] Univ Magdeburg, Inst Chem, D-39106 Magdeburg, Germany

[2] Swiss Fed Inst Technol, Dept Chem & Appl BioSci, Inst Pharmaceut Sci, CH-8057 Zurich, Switzerland

来源：

SYNLETT | 2004年 / 08期

关键词：

epothilone; total synthesis; furans; ring closure; macrocycles;

D O I：

10.1055/s-2004-829071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of furano-epothilone C (1) is described by the use of an aldol reaction and a ring-closing metathesis (RCM) for the closure of the macrocyclic ring system. This new type of analog contains a furan ring in the C8-C10 region of the macrocycle. The biology of this new class of epothilone C analog has been studied.

引用

页码：1375 / 1378

页数：4

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