The effect of citalopram treatment on platelet serotonin function in panic disorders

被引:25
作者
Neuger, J [1 ]
Wistedt, B
Sinner, B
Åberg-Wistedt, A
Stain-Malmgren, R
机构
[1] St Gorans Hosp, Dept Clin Neurosci, Psychiat Clin, Karolinska Inst,Inst Clin Neurosci, SE-11281 Stockholm, Sweden
[2] Danderyd Hosp, Dept Psychiat, Stockholm, Sweden
关键词
5-HT2-receptor; panic disorder; paroxetine-binding; platelets; serotonin uptake;
D O I
10.1097/00004850-200015020-00004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated the effect of the selective serotonin reuptake inhibitor (SSRI) citalopram after 6-8 weeks and 6 months of treatment on clinical and peripheral indexes for central serotonergic function: platelet [C-14]serotonin uptake and [H-3]paroxetine- and [H-3]LSD-binding to platelets membranes in 33 patients with panic disorder. Basal data from patients were compared with data from a control material consisting of 33 healthy volunteers. B-max for platelet [H-3]paroxetine binding was significantly lower in patients than in controls. There were no differences in serotonin uptake or [H-3]LSD-binding between patients and controls. The degree of anxiety and depression was assessed using the Beck Anxiety Inventory (BAI) and Beck Depression Inventory self-assessment scales, and the Clinical Anxiety Scale and the Montgomery Asberg Depression Rating Scale for clinical evaluation. Complete remission was found in one third of the patients after 6-8 weeks and in two-thirds after 6 months of treatment. The reduction in assessment scores was parallelled with similar reductions in platelet 5-HT2-receptor density, [H-3]LSD affinity variable (K-d) and V-max for platelet [C-14]5-HT uptake. Citalopram treatment did not alter B-max and K-d for platelet [H-3]paroxetine-binding. A positive correlation was found between V-max for the platelet [C-14]5-HT uptake and BAI after 6 months citalopram treatment. The present study shows that citalopram has a therapeutic effect in panic disorders. A prerequisite of responding to treatment might be plasticity in the serotonergic system. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:83 / 91
页数:9
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