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Genome-based pharmacogenetics and the pharmaceutical industry

被引：104
作者：
Roses, AD [1 ]
机构：
[1] GlaxoSmithKline, Genet Res, Res Triangle Pk, NC 27709 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 07期
关键词：
D O I：
10.1038/nrd840
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Pharmacogenetic capabilities have changed markedly since The SNP Consortium made a dense single-nucleotide polymorphism (SNP) map freely available in 2001. For more than 40 years, pharmacokinetics and pharmacodynamics of drug-metabolizing molecules were the focus of practical applications. Today, it is possible to use SNP-mapping technologies to create a genetic profile of each individual that can be used to identify patterns of susceptibility genes for common diseases as well as genetic risk/efficacy factors that are related to the effects of drugs.
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页码：541 / 549
页数：9
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