In vitro and in vivo properties of murine monoclonal antibody for a novel immature thymocyte-differentiated antigen, JL1

被引：6

作者：

Chung, JK ^{[1
]}

So, Y ^{[1
]}

Hong, MK ^{[1
]}

Choi, SR ^{[1
]}

Jeong, JM ^{[1
]}

Lee, DS ^{[1
]}

Lee, MC ^{[1
]}

Koh, CS ^{[1
]}

Choi, EY ^{[1
]}

Park, SH ^{[1
]}

机构：

[1] SEOUL NATL UNIV HOSP,DEPT PATHOL,SEOUL 110744,SOUTH KOREA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 05期

关键词：

monoclonal antibody; JL1; antigen; leukemia; lymphoma;

D O I：

10.1016/S0969-8051(97)00026-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

JL1 is a novel thymocyte-differentiated antigen strictly confined to stage II immature cortical thymocytes. It is expressed in several types of leukemias and lymphomas. Murine anti-JL1 monoclonal antibody labeled with I-131 and Tc-99m showed 60-70% of immunoreactivity and 1.4-1.9 x 10(9) L/mol of affinity constant. The incubation of the radiolabeled antibody with Molt-4 cells showed no evidence of modulation or shedding. Localization indices increased from day 3 to day 5 in SCID mice bearing Molt-4 cells. (C) 1997 Elsevier Science Inc.

引用

页码：433 / 437

页数：5

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