Colocalization of 5-HT1F receptor and glutamate in neurons of the vestibular nuclei in rats

被引：17

作者：

Ahn, Seong-Ki ^{[1
,2
]}

Khalmuratova, Roza ^{[1
]}

Jeon, Sea-Yuong ^{[1
,2
]}

Kim, Jin-Pyeong ^{[1
,2
]}

Park, Jung-Je ^{[1
,2
]}

Hur, Dong-Gu ^{[1
]}

Kim, Dae-Woo ^{[1
]}

Balaban, Carey D. ^{[3
]}

机构：

[1] Gyeongsang Natl Univ, Coll Med, Dept Otolaryngol, Jinju 660702, South Korea

[2] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Jinju 660702, South Korea

[3] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15260 USA

来源：

NEUROREPORT | 2009年 / 20卷 / 02期

关键词：

5-HT1F; glutamate; migraine; vertigo; vestibular nuclei; MOTION SICKNESS; MIGRAINE; AGONISTS; VERTIGO;

D O I：

10.1097/WNR.0b013e328320795e

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Interplay between migraine and balance disorder morbidities has been a topic of interest for many years. Serotonin (5-HT) receptor is closely related with migraine and is associated with vestibular symptoms. The mechanism underlying migrainous vertigo, however, has not been determined. 5-HT1F receptor has recently attracted attention in the treatment of migraine, and the release of glutamate from trigeminal neurons has been implicated in migraine. In this study, the authors observed the colocalization of 5-HT1F receptor and glutamate in the vestibular nuclei of rats using double immunofluorescence, which suggests that 5-HT1F receptor might modulate glutamate release from the vestibular nuclei. The results of this study suggest that 5-HT1F receptor agonists represent a potential therapeutic strategy for migraine and balance disorders by blocking the release of glutamate. NeuroReport 20:111-115 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：111 / 115

页数：5

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