In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages

被引：55

作者：

Rodrigues, T. G. ^{[1
]}

Fernandes, A., Jr. ^{[1
]}

Sousa, J. P. B. ^{[2
]}

Bastos, J. K. ^{[2
]}

Sforcin, J. M. ^{[1
]}

机构：

[1] UNESP, Biosci Inst, Dept Microbiol & Immunol, Botucatu, SP, Brazil

[2] Univ Sao Paulo, Lab Pharmacognosy, Sch Pharmaceut Sci Ribeira Preto, Dept Pharmaceut Sci, Ribeirao Preto, SP, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

clove; essential oil; macrophages; cytokines; KAPPA-B; ACTIVATION; EXPRESSION; PLANT; CYCLOOXYGENASE-2; PROPOLIS; EXTRACTS; PLASMA;

D O I：

10.1080/14786410802242679

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Biological properties of clove have been reported, but little is known about its effect on the immune system. This work was aimed to investigate the effect in vivo of a water-soluble part of hydroalcoholic extract of clove on pro-inflammatory cytokines (IL-1 and IL-6) production by macrophages of BALB/c mice. The action of the essential oil of clove on the production of these cytokines macrophages was also investigated in vitro. The chemical compositions of the extract and of the oil were also investigated. Treatment of mice with water extract of clove was found to inhibit macrophages to produce both IL-1 and IL-6. The essential oil of clove also inhibited the production of these cytokines in vitro. Eugenol was found to be the major component of the clove extract and essential oil, and probably is the causative agent of cytokine inhibition. Taken together, these data suggest an anti-inflammatory action of this spice.

引用

页码：319 / 326

页数：8

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