MLL amplification in myeloid malignancies:: clinical, molecular, and cytogenetic findings

被引:35
作者
Dolan, M [1 ]
McGlennen, RC [1 ]
Hirsch, B [1 ]
机构
[1] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
关键词
D O I
10.1016/S0165-4608(01)00602-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Structural rearrangements involving the MLL gene at l1q23 are common recurring abnormalities in de novo and therapy-related hematologic disorders. MLL rearrangement most often results from translocation or partial tandem duplication, although recent published reports suggest a different mechanism by which MLL might participate in leukemogenesis: MLL amplification. We report two patients with myeloid disorders who showed amplification of MLL at diagnosis and who, like the majority of reported cases, had an older age at onset and on aggressive clinical course. Additionally, we summarize the salient clinical, cytogenetic and molecular findings of the 29 other cases of MLL amplification that have thus far been reported. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:93 / 101
页数:9
相关论文
共 38 条
[1]   Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements [J].
Andreasson, P ;
Johansson, B ;
Billström, R ;
Garwicz, S ;
Mitelman, F ;
Höglund, M .
LEUKEMIA, 1998, 12 (03) :390-400
[2]  
[Anonymous], 1983, COLD SPRING HARBOR L
[3]  
Ariyama Y, 1998, GENE CHROMOSOME CANC, V23, P267, DOI 10.1002/(SICI)1098-2264(199811)23:3<267::AID-GCC10>3.3.CO
[4]  
2-0
[5]  
Avet-Loiseau H, 1999, GENE CHROMOSOME CANC, V26, P166, DOI 10.1002/(SICI)1098-2264(199910)26:2<166::AID-GCC9>3.0.CO
[6]  
2-P
[7]   Myelodysplastic syndromes associated with 11q23 abnormalities [J].
Bain, BJ ;
Moorman, AV ;
Johansson, B ;
Mehta, AB ;
Secker-Walker, LM .
LEUKEMIA, 1998, 12 (05) :834-839
[8]   MOLECULAR-BASIS OF 11Q23 REARRANGEMENTS IN HEMATOPOIETIC MALIGNANT PROLIFERATIONS [J].
BERNARD, OA ;
BERGER, R .
GENES CHROMOSOMES & CANCER, 1995, 13 (02) :75-85
[9]  
Caligiuri MA, 1996, CANCER RES, V56, P1418
[10]  
CHEN CS, 1993, BLOOD, V81, P2386