Hydrogels in endovascular embolization .6. Toxicity tests of poly(2-hydroxyethyl methacrylate) particles on cell cultures

被引：36

作者：

Horak, D ^{[1
]}

Cervinka, M ^{[1
]}

Puza, V ^{[1
]}

机构：

[1] CHARLES UNIV,FAC MED,HRADEC KRALOVE 50001,CZECH REPUBLIC

来源：

BIOMATERIALS | 1997年 / 18卷 / 20期

关键词：

poly(2-hydroxyethyl methacrylate); hydrogels; cytotoxicity; contact test; extraction test; cell proliferation;

D O I：

10.1016/S0142-9612(97)00059-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cytotoxicity of poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydrogel spherical particles, prepared by radical suspension polymerization and designed for endovascular occlusion, was studied in vitro on cell cultures. Testing methods included a direct contact test and extraction test. No inhibition of growth of cells surrounding the poly(HEMA) beads and a Very low inhibition of cell viability, only in concentrated extracts in long-term contact, were observed. As a result, poly(HEMA) beads can be considered non-toxic. (C) 1997 Elsevier Science Limited. All rights reserved.

引用

页码：1355 / 1359

页数：5

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