Anti-melanin antibodies are increased in sera in Parkinson's disease

被引：69

作者：

Double, K. L. ^{[1
,2
]}

Rowe, D. B. ^{[3
]}

Carew-Jones, F. M. ^{[1
,2
]}

Hayes, M. ^{[4
]}

Chan, D. K. Y. ^{[5
,6
]}

Blackie, J. ^{[7
]}

Corbett, A. ^{[4
]}

Joffe, R. ^{[3
]}

Fung, V. S. ^{[8
]}

Morris, J. ^{[8
]}

Riederer, P. ^{[9
,10
]}

Gerlach, M. ^{[11
]}

Halliday, G. M. ^{[1
,2
]}

机构：

[1] Prince Wales Med Res Inst, Randwick, NSW 2031, Australia

[2] Univ New S Wales, Randwick, NSW 2031, Australia

[3] Macquarie Univ, Australian Sch Adv Med, N Ryde, NSW 2109, Australia

[4] Concord Hosp, Dept Neurol, Sydney, NSW 2139, Australia

[5] Bankstown Hosp, Dept Aged Care & Rehabil, Sydney, NSW 2200, Australia

[6] Univ New S Wales, Sydney, NSW 2200, Australia

[7] John Hunter Hosp, Dept Neurol, Newcastle, NSW 2310, Australia

[8] Westmead Hosp, Dept Neurol, Sydney, NSW 2145, Australia

[9] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, D-97070 Wurzburg, Germany

[10] Univ Wurzburg, Natl Parkinson Fdn Ctr Excellence Neurodegenerat, D-97070 Wurzburg, Germany

[11] Univ Wurzburg, Dept Child & Adolescene Psychiat Psychosomat & Ps, D-97070 Wurzburg, Germany

来源：

EXPERIMENTAL NEUROLOGY | 2009年 / 217卷 / 02期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease; Humoral immune response; Autoantibodies; Neuromelanin; Olfactory function; Sera; HUMAN SUBSTANTIA-NIGRA; HUMAN NEUROMELANIN; PROTEIN; PROGRESSION;

D O I：

10.1016/j.expneurol.2009.03.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel ELISA for anti-melanin antibodies, compared to sera from age-matched control subjects. The enhanced ELISA absorbance response was specific for catecholamine-based melanins and was unrelated to antiparkinsonian dopaminergic medication. Further, the absorbance response was significantly and negatively correlated with disease duration. These data suggest that a specific humoral anti-melanin antibody response is present in PD and is more active in early disease. While the contribution of this novel immune response to the initiation and progression of this disorder is unclear, this finding supports the hypothesis that specific immune responses occurring in PD may respond to therapeutic interventions in this disorder. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：297 / 301

页数：5

共 27 条

[1] Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits [J].

Beach, Thomas G. ;

Sue, Lucia I. ;

Walker, Douglas G. ;

Lue, Lih Fen ;

Connor, Donald J. ;

Caviness, John N. ;

Sabbagh, Marwan N. ;

Adler, Charles H. .

ACTA NEUROPATHOLOGICA, 2007, 114 (04) :419-424

[2] Inflamm-aging: autoimmunity, and the immune-risk phenotype [J].

Boren, E ;

Gershwin, ME .

AUTOIMMUNITY REVIEWS, 2004, 3 (05) :401-406

[3] Validating a screening questionnaire for parkinsonism in Australia [J].

Chan, DKY ;

Hung, WT ;

Wong, A ;

Hu, E ;

Beran, RG .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 69 (01) :117-120

[4] A population perspective on diagnostic criteria for Parkinson's disease [J].

deRijk, MC ;

Rocca, WA ;

Anderson, DW ;

Melcon, MO ;

Breteler, MMB ;

Maraganore, DM .

NEUROLOGY, 1997, 48 (05) :1277-1281

[5] Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins [J].

Double, KL ;

Zecca, L ;

Costi, P ;

Mauer, M ;

Griesinger, C ;

Ito, S ;

Ben-Shachar, D ;

Bringmann, G ;

Fariello, RG ;

Riederer, P ;

Gerlach, M .

JOURNAL OF NEUROCHEMISTRY, 2000, 75 (06) :2583-2589

[6] Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test [J].

Double, KL ;

Rowe, DB ;

Hayes, M ;

Chan, DKY ;

Blackie, J ;

Corbett, A ;

Fung, VS ;

Morris, J ;

Halliday, GM .

ARCHIVES OF NEUROLOGY, 2003, 60 (04) :545-549

[7] Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson's disease [J].

El-Agnaf, Omar M. A. ;

Salem, Sultan A. ;

Paleologou, Katerina E. ;

Curran, Martin D. ;

Gibson, Mark J. ;

Court, Jennifer A. ;

Schlossmacher, Michael G. ;

Allsop, David .

FASEB JOURNAL, 2006, 20 (03) :419-425

[8] Is neuromelanin changed in Parkinson's disease? Investigations by magnetic spectroscopies [J].

Fasano, M ;

Bergamasco, B ;

Lopiano, L .

JOURNAL OF NEURAL TRANSMISSION, 2006, 113 (06) :769-774

[9] G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences [J].

Faul, Franz ;

Erdfelder, Edgar ;

Lang, Albert-Georg ;

Buchner, Axel .

BEHAVIOR RESEARCH METHODS, 2007, 39 (02) :175-191

[10] AGING AND PARKINSONS-DISEASE - SUBSTANTIA-NIGRA REGIONAL SELECTIVITY [J].

FEARNLEY, JM ;

LEES, AJ .

BRAIN, 1991, 114 :2283-2301

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