An Extremely Facile Synthesis of Furans, Pyrroles, and Thiophenes by the Dehydrative Cyclization of Propargyl Alcohols

被引：215

作者：

Aponick, Aaron ^{[1
]}

Li, Chuan-Ying ^{[1
]}

Malinge, Jeremy ^{[1
]}

Marques, Emerson Finco ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

关键词：

HOMOGENEOUS GOLD CATALYSIS; HIGHLY SUBSTITUTED FURANS; 2,3-DISUBSTITUTED FURANS; CYCLOISOMERIZATION; HETEROCYCLES; CARBOCYCLES; ALKYNES;

D O I：

10.1021/ol901901m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Furans, pyrroles, and thiophenes are efficiently prepared by gold-catalyzed dehydrative cyclizations of readily available, heteroatom-substituted propargylic alcohols. The reactions are rapid, high-yielding, and procedurally simple, giving essentially pure aromatic heterocycles in minutes under open-flask conditions with catalyst loadings as low as 0.05 mol %.

引用

收藏

页码：4624 / 4627

页数：4

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