The fundamental role of epigenetic events in cancer

被引：4609

作者：

Jones, PA

Baylin, SB

机构：

[1] USC, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Urol, Los Angeles, CA 90089 USA

[2] USC, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Biochem, Los Angeles, CA 90089 USA

[3] USC, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Dept Mol Biol, Los Angeles, CA 90089 USA

[4] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[5] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Dept Med, Baltimore, MD 21231 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 06期

关键词：

D O I：

10.1038/nrg816

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia and include genome-wide losses of, and regional gains in, DNA methylation. The recent explosion in our knowledge of how chromatin organization modulates gene transcription has further highlighted the importance of epigenetic mechanisms in the initiation and progression of human cancer. These epigenetic changes - in particular, aberrant promoter hypermethylation that is associated with inappropriate gene silencing - affect virtually every step in tumour progression. In this review, we discuss these epigenetic events and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.

引用

页码：415 / 428

页数：14

共 113 条

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