Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3-CD4+CD45+ cells

被引：168

作者：

Fukuyama, S

Hiroi, T

Yokota, Y

Rennert, PD

Yanagita, M

Kinoshita, N

Terawaki, S

Shikina, T

Yamamoto, M

Kurono, Y

Kiyono, H

机构：

[1] Osaka Univ, Dept Mucosal Immunol, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

[2] Fukui Med Univ, Dept Biochem 1, Matsuoka, Fukui 9101193, Japan

[3] Biogen Inc, Cambridge, MA 02142 USA

[4] Nihon Univ, Sch Dent, Dept Oral Med, Matsudo, Chiba 2718587, Japan

[5] Kagoshima Univ, Fac Med, Dept Otolaryngol, Kagoshima 8908520, Japan

[6] Univ Alabama, Immunobiol Vaccine Ctr, Birmingham, AL 35294 USA

[7] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo 1088639, Japan

来源：

IMMUNITY | 2002年 / 17卷 / 01期

关键词：

D O I：

10.1016/S1074-7613(02)00339-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3-CD4+CD45+ inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.

引用

页码：31 / 40

页数：10

共 41 条

[1] Three distinctive steps in Peyer's patch formation of murine embryo [J].