Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer

被引：28

作者：

Altena, R. ^{[1
,5
]}

de Haas, E. C. ^{[1
,5
]}

Nuver, J. ^{[1
,5
]}

Brouwer, C. A. J. ^{[2
,5
]}

van den Berg, M. P. ^{[3
,5
]}

Smit, A. J. ^{[4
,5
]}

Postma, A. ^{[2
,5
]}

Sleijfer, D. Th ^{[1
,5
]}

Gietema, J. A. ^{[1
,5
]}

机构：

[1] Univ Med Ctr Groningen, Dept Med Oncol, NL-9700 RB Groningen, Netherlands

[2] Univ Med Ctr Groningen, Dept Paediat Oncol, NL-9700 RB Groningen, Netherlands

[3] Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands

[4] Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands

[5] Univ Groningen, NL-9700 RB Groningen, Netherlands

来源：

BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 12期

关键词：

testicular cancer; cardiovascular toxicity; echocardiography; prospective; LONG-TERM SURVIVORS; VENTRICULAR EJECTION FRACTION; DIASTOLIC HEART-FAILURE; CONVENTIONAL ECHOCARDIOGRAPHY; CARDIOVASCULAR-DISEASE; NATRIURETIC PEPTIDE; METABOLIC SYNDROME; CARDIOTOXICITY; ANTHRACYCLINES; CARDIOLOGY;

D O I：

10.1038/sj.bjc.6605095

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long-term cardiovascular morbidity is increasingly observed in chemotherapy-treated testicular cancer survivors, but little is known of early sub-clinical changes in cardiac function. We prospectively evaluated cardiac function in testicular cancer patients by echocardiography. Systolic (Wall Motion Score Index) and diastolic (E/A-ratio and Tissue Velocity Imaging (TVI)) parameters, and serum levels of N-Terminal pro-Brain Natriuretic Peptide (NT-proBNP) were assessed before the start of chemotherapy and 1 year later. Echocardiography data were compared with an age-matched group of healthy controls. Forty-two patients treated with bleomycin, etoposide and cisplatin were evaluated (median age 27 years, range 18-50). Systolic function and E/A-ratio did not change, whereas the median TVI decreased (12.0 vs 10.0 cm s(-1); P = 0.002). Median levels of NT-proBNP increased (5 vs 18 pmol l(-1), P = 0.034). Compared with controls, TVI before the start of chemotherapy was not significantly different. In conclusion, we found that at a median of 10 months after cisplatin-based treatment for testicular cancer, TVI decreased significantly, indicating a deterioration of diastolic cardiac function. Serum levels of NT-proBNP increased. The prognostic significance of these changes for future cardiovascular morbidity is not clear. British Journal of Cancer (2009) 100, 1861-1866. doi: 10.1038/sj.bjc.6605095 www.bjcancer.com Published online 19 May 2009 (C) 2009 Cancer Research UK

引用

页码：1861 / 1866

页数：6

共 27 条

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