TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells

被引:51
作者
Badovinac, Vladimir P.
Messingham, Kelly A. Nordyke
Griffith, Thomas S.
Harty, John T.
机构
[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Urol, Iowa City, IA 52242 USA
[3] Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
关键词
D O I
10.4049/jimmunol.177.2.999
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this study, we investigated the role of TRAIL in Ag-specific CD8 T cell homeostasis after viral infection. TRAIL deficiency does not influence the kinetics of the Ag-specific CD8 T cell responses, and CD8 T cells in TRAIL-deficient mice were able to expand, contract, and generate functional memory cell numbers that were indistinguishable from TRAIL-sufficient wild-type CD8 T cells after acute lymphocytic choriomeningitis virus infection. Interestingly, the ability of "helpless" CD8 T cells to retain their memory phenotypic and functional (i.e., secondary expansion) characteristics was prolonged in TRAIL-deficient mice compared with wild-type CD4-depleted controls. However, TRAIL deficiency only delayed, but did not prevent, the eventual erosion in the quality of helpless memory CD8 T cells, and that correlated with their inability to respond to a second round of Ag-driven proliferation. These data, which suggest that CD4 help consists of both TRAIL-dependent and -independent components, may help to resolve the current controversy between the early programming and maintenance models that were put forward to explain the role of CD4 T cell help in Ag-specific CD8 T cell homeostasis.
引用
收藏
页码:999 / 1006
页数:8
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